On the synthesis of 4-and 5-pyrimidinyl-diphenyl-(1-imidazolyl) methanes and their antifungal activity

Z Buděšínský, J Vavřina, L Langšádl…

Index: Budesinsky; Vavrina; Langsadl; Holubek Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 2 p. 539 - 547

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Citation Number: 4

Abstract

Abstract On reaction of phenylmagnesium bromide with ethyl ester of 5-chloro-2-methyl-, 5- chloro-2-methylthio-, 5-bromo-2-methylthio-4-pyrimidinecarboxylic acid and 2, 4-dimethyl-5- pyrimidinecarboxylic acid (IIa, IIb, IIc, V) corresponding 4-pyrimidinyl-or 5-pyrimidinyl- diphenylmethanols (IIIa, IIIb, IIIc, VI) were obtained. On reaction of thionyl-bis-imidazole with these methanols (4-or 5-pyrimidinyl)-diphenyl-(1-imidazolyl)-methanes IVa, IVb, IVc and ...