Tetrahedron: Asymmetry

Enzymatic resolution of 2, 2-disubstituted-1, 3-dioxolane-4-methanol carboxylic esters

V Partali, AG Melbye, T Alvik, T Anthonsen

Index: Partali; Melbye; Alvik; Anthonsen Tetrahedron Asymmetry, 1992 , vol. 3, # 1 p. 65 - 72

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Citation Number: 22

Abstract

Abstract The enantioselectivity of enzymatic hydrolysis of carboxylic esters of various 1, 2- ketals of glycerol has been investigated. The influence of the ketal group has been studied. A number of lipases and proteinases have been tested and the best enantioselectivity was obtained with proteinase from Aspergillus oryzae which gave an E-value of 9 with 2, 2- dimethyl-1, 3-dioxolane-4-methanol butanoate. Variations in the acyl part revealed that ...