Tetrahedron

Synthesis of 2, 3-disubstituted pyrazines and quinoxalines by Heck cross-coupling reactions of 2, 3-dichloropyrazine and 2, 3-dichloroquinoxaline. Influence of the …

…, A Ali, SMT Toguem, FZ Basha, C Fischer, P Langer

Index: Malik, Imran; Hussain, Munawar; Ali, Asad; Tengho Toguem, Serge-Mitherand; Basha, Fatima Z.; Fischer, Christine; Langer, Peter Tetrahedron, 2010 , vol. 66, # 9 p. 1637 - 1642

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Citation Number: 18

Abstract

2,3-Dichloropyrazine and 2,3-dichloroquinoxaline represent useful building blocks for the synthesis of substituted and annulated pyrazines and quinoxalines. Condensed heterocycles have been prepared by cyclization of 2,3-dichloropyrazine with 2-aminobenzenethiol, 11 2-aminophenol, 12 3-hydroxy-1H-pyridine-2-thione, 13 3-amino-6-methoxy-1H-pyridine-2-thione , 14 2-amino-benzeneselenol, 15 and pyrid-2-yl-acetonitrile. 16 Open-chained pyrazines ...