Synthesis of new didemnin B analogs for investigations of structure/biological activity relationships

…, J Ramanjulu, MD Vera, AJ Pfizenmayer…

Index: Mayer; Ramanjulu; Vera; Pfizenmayer; Joullie Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5192 - 5205

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Citation Number: 62

Abstract

The didemnins (1) are a class of novel cyclodepsipeptides isolated in the Caribbean from a marine tunicate of the family Didemnidae (Trididemnum genus) by Rinehart and co-workers in 1981 using extraction and column chromatography.'Didemnins AC (la-lc) contain a common macrocycle and differ only in the side chains attached to the backbone through the amino group of threonine (Chart 1). They have been the subject of much study because of ...