N-Alkenyl and cycloalkyl carbamates as dual acting histamine H 3 and H 4 receptor ligands

…, H Stark, J Handzlik, K Kieć-Kononowicz

Index: Wicek, Malgorzata; Kottke, Tim; Ligneau, Xavier; Schunack, Walter; Seifert, Roland; Stark, Holger; Handzlik, Jadwiga; Kiec-Kononowicz, Katarzyna Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2850 - 2858

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Citation Number: 17

Abstract

Abstract Previous studies have shown that several imidazole derivatives posses affinity to histamine H 3 and H 4 receptors. Continuing our study on structural requirements responsible for affinity and selectivity for H 3/H 4 receptor subtypes, two series of 3-(1H- imidazol-4-yl) propyl carbamates were prepared: a series of unsaturated alkyl derivatives (1– 9) and a series possessing a cycloalkyl group different distances to the carbamate moiety ...