Peptide receptor agonists and antagonists often contain a tyrosine residue which is important to binding. Recently we developed a series of nonpeptide angiotensin I1 antagonists based on an overlay hypothesis in which the tyrosine 4-hydroxybenzyl side- chain of angiotensin I1 was mimicked by a 4-carboxybenzyl in the non-peptide antagonist. Therefore, we thought it would be interesting to determine if the 4-carboxyphenylalanine ...
