The preparation of 2, 6??diaminopyrazine, 2, 6??diazidopyrazine and some of their derivatives

…, CE Brotherton, RW Moon, MD Winland…

Index: Shaw, John T.; Brotherton, Christine E.; Moon, Robert W.; Winland, Mark D.; Anderson, Mark D.; Kyler, Keith S. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 11 - 16

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Citation Number: 12

Abstract

Abstract A much improved synthesis of the heretofore difficultly obtainable 2, 6- diaminopyrazine (4) was afforded by the low-pressure catalytic hydrogenation (palladium on carbon) of 2, 6-diazido-pyrazine (2); reaction of 2, 6-dichloropyrazine (1) and sodium azide gave 2 in 84% yield. The outcome of the reduction was found to be solvent dependent: 1, 2- dimethoxyethane containing aqueous ammonia gave 4 in 83% yield; 1, 2- ...