Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino) phenylacetic acids and acyl sulfonamides

DS Dhanoa, SW Bagley, RSL Chang…

Index: Dhanoa, Daljit S.; Bagley, Scott W.; Chang, Raymond S. L.; Lotti, Victor J.; Chen, Tsing-Bau; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4239 - 4249

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Citation Number: 22

Abstract

Inhibition of the renin-angiotensin system (RAS) by angiotensin I1 (AII) receptor antagonists continues to be the most active area of drug discovery for the treatment of hypertension and congestive heart fail~ re.~ Recently, we have described a new class of potent AT1-selective AI1 receptor antagonists derived from N-substituted indoles and dihydr~ indoles.~ In our continuing efforts to discover a structurally distinct class of AI1 antagonists, we became ...