Tetrahedron letters

Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

SA Ohnmacht, T Brenstrum, KH Bleicher, J McNulty…

Index: Ohnmacht, Stephan A.; Brenstrum, Tim; Bleicher, Konrad H.; McNulty, James; Capretta, Alfredo Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5661 - 5663

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Citation Number: 28

Abstract

The use of a catalyst system based on Pd2dba3· CHCl3 and 1, 3, 5, 7-tetramethyl-2, 4, 8- trioxa-6-phenyl-6-phospha-adamantane allows for Suzuki coupling aryl halides with an array of boronic acids on a solid-phase platform. The reactions can be carried out at room temperature with low palladium loadings in high yields.