We recently reported the properties of the first selective inhibitors of herpes simplex virus type 1 (HSV1) uracil-DNA glycosylase (UDG), an enzyme of DNA repair that has been proposed to be required for reactivation of the virus from latency. 6-(4-Octylanilino) uracil (octAU) was the most potent inhibitor among a series of 6-(4-alkylanilino) uracils, acting in the micromolar range and without effect against human UDG. A 28.5-kDa catalytic ...
