Evaluation of α-pyrones and pyrimidones as photoaffinity probes for affinity-based protein profiling

OA Battenberg, MB Nodwell…

Index: Battenberg, Oliver A.; Nodwell, Matthew B.; Sieber, Stephan A. Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6075 - 6087

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Citation Number: 7

Abstract

α-Pyrones and pyrimidones are common structural motifs in natural products and bioactive compounds. They also display photochemistry that generates high-energy intermediates that may be capable of protein reactivity. A library of pyrones and pyrimidones was synthesized, and their potential to act as photoaffinity probes for nondirected affinity-based protein profiling in several crude cell lysates was evaluated. Further “proof-of-principle” ...