Ten oxazoles bearing a C (4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C (2) position of the oxazole ring reveals that a 3, 5-dichlorophenyl substituent significantly reduced amyloidogenesis. The efficacy of these inhibitors was enhanced further by installing an ethyl, a propyl, or a CF3 group at the C (5) position. The CF3 substitution at C (5) also ...
