Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

J Cao, H Gao, G Bemis, F Salituro, M Ledeboer…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 10 p. 2891 - 2895

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Citation Number: 24

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... In this Letter, we present optimization of an isatin oxime screening hit through application of a combination of parallel synthesis and X-ray crystallography to develop potent and selective JNK3 inhibitors. ...

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