Coumarins. I. Derivatives of Coumarin-3-and 4-Carboxylic Acids

RO Clinton, SC Laskowski

Index: Clinton; Laskowski Journal of the American Chemical Society, 1949 , vol. 71, p. 3602,3604

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Citation Number: 26

Abstract

With the exception of a brief publication by Werder, no pharmacological or chemical investigations appear to have been made of the basic esters and amides derivable from coumarins. Werderlavc found that N, N-dialkyl-coumarin-3-carboxamides2 exhibited remarkable sedative properties, and it is of considerable significance that they also had but slight toxicity. Furthermore, the favorable toxicity indices of coumarin-3-carboxylic acid ...