Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 2-phenyl-4'-(2, 3, 4, 5-tetrahydro-1H-1, 5- …

A Matsuhisa, H Koshio, K Sakamoto…

Index: Chemical and Pharmaceutical Bulletin, , vol. 46, # 10 p. 1566 - 1579

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Citation Number: 30

Abstract

... Chemistry The synthetic pathway for the preparation of the benzodi- azepine derivatives listed in Tables 1—5 is shown in Charts l»—3. 1,4-Benzodiazepine derivatives were synthesized ac- cording to the route shown in Chart 1 ... 1998 Pharmaceutical Society of ... 1570 Vol. ...