Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids

P Senthilkumar, M Dinakaran, P Yogeeswari…

Index: Senthilkumar, Palaniappan; Dinakaran, Murugesan; Yogeeswari, Perumal; Sriram, Dharmarajan; China, Arnab; Nagaraja, Valakunja European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 345 - 358

Full Text: HTML

Citation Number: 45

Abstract

Various 1-(substituted)-1, 4-dihydro-6-nitro-4-oxo-7-(sub-secondary amino)-quinoline-3- carboxylic acids were synthesized from 2, 4-dichlorobenzoic acid by six step synthesis. The compounds were evaluated for antimycobacterial in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC2) and also tested for the ability to inhibit the supercoiling ...