Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo [1, 2-a] quinoxalines as antileishmanial agents–Part III

…, S Daulouede, P Vincendeau, N Farvacques…

Index: Ronga, Luisa; Del Favero, Marco; Cohen, Anita; Soum, Claire; Le Pape, Patrice; Savrimoutou, Solene; Pinaud, Noel; Mullie, Catherine; Daulouede, Sylvie; Vincendeau, Philippe; Farvacques, Natacha; Agnamey, Patrice; Pagniez, Fabrice; Hutter, Sebastien; Azas, Nadine; Sonnet, Pascal; Guillon, Jean European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 378 - 393

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Citation Number: 7

Abstract

Abstract A series of new 4-alkapolyenylpyrrolo [1, 2-a] quinoxaline derivatives, original and structural analogues of alkaloid chimanine B and of previously described 4-alkenylpyrrolo [1, 2-a] quinoxalines, was synthesized in good yields using efficient palladium-catalyzed Suzuki–Miyaura cross-coupling reactions. These new compounds were tested for in vitro antiparasitic activity upon three Leishmania spp. strains. Biological results showed activity ...