Tetrahedron

New procedures for the synthesis of heterocyclic substituted and 2, 4-difunctionalized pyrimidines

AG Martínez, AH Fernández, FM Jiménez…

Index: Garcia Martinez, Antonio; Herrera Fernandez, Antonio; Moreno Jimenez, Florencio; Munoz Martinez, Pablo J.; Alonso Martin, Cristina; Subramanian, Laksminarayanapuran R. Tetrahedron, 1996 , vol. 52, # 23 p. 7973 - 7982

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Citation Number: 13

Abstract

N-Tosyl-2-and-3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2, 4- Difunctionalized pyrimidines were obtained by reaction of the corresponding 2, 4-bis (methylsulfonyl) pyrimidines with nucleophiles.