3-[(2-Ethoxyphenoxy) methyl] piperidine derivatives. Synthesis and antidepressant activity

…, A Lucacchini, B Macchia, F Macchia…

Index: Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225

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Citation Number: 6

Abstract

The 3-1 (2-ethoxyphenoxy) methyl] piperidine derivatives 3-5 were synthesized and screened as potential antidepressant agents by the reserpine interaction test in mice and the evaluation of reuptake inhibition of biogenic amines in pig brain synaptosomal fractions. In addition, their anticonvulsant activity, tested by pentylenetetrazole antagonism, and approximate acute toxicity were evaluated. In vivo and in vitro tests showed that ...