… agents-Part 1: Antiinflammatory, analgesic and antipyretic activity of some new 1-(pyrimidin-2-yl)-3-pyrazolin-5-ones and 2-(pyrimidin-2-yl)-1, 2, 4, 5, 6, 7-hexahydro- …

ESAM Badawey, IM El-Ashmawey

Index: Badawey, El-Sayed A. M.; El-Ashmawey, Ibrahim M. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 349 - 361

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Citation Number: 107

Abstract

In our reinvestigation of the cyclocondensation reaction of aminoguanidine bicarbonate 1 with 2-acetylbutyrolactone 2 and ethyl cyclohexanone-2-carboxylate 6, we have obtained the respective 1-amidino-3-pyrazolin-5-one derivative 3 and the 2-amidino-1, 2, 4, 5, 6, 7- hexahydro-3H-indazol-3-one 7. These intermediates were utilized for the synthesis of two novel series of 1-(pyrimidin-2-yl)-3-pyrazolin-5-ones and 2-(pyrimidin-2-yl)-1, 2, 4, 5, 6, 7- ...