A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

…, S Alfonso, GC Porretta, S Consalvi, L Sautebin…

Index: Battilocchio, Claudio; Poce, Giovanna; Alfonso, Salvatore; Porretta, Giulio Cesare; Consalvi, Sara; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Schenone, Silvia; Giordani, Antonio; Di Francesco, Luigia; Patrignani, Paola; Biava, Mariangela Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3695 - 3701

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Citation Number: 13

Abstract

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti- nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.