Selective catalysis with peptide dendrimers

C Douat-Casassus, T Darbre…

Index: Douat-Casassus, Celine; Darbre, Tamis; Reymond, Jean-Louis Journal of the American Chemical Society, 2004 , vol. 126, # 25 p. 7817 - 7826

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Citation Number: 79

Abstract

Peptide dendrimers incorporating 3, 5-diaminobenzoic acid 1 as a branching unit (B) were prepared by solid-phase synthesis of ((Ac-A3) 2B-A2) 2B-Cys-A1-NH2 followed by disulfide bridge formation. Twenty-one homo-and heterodimeric dendrimers were obtained by permutations of aspartate, histidine, and serine at positions A1, A2, and A3. Two dendrimers catalyzed the hydrolysis of 7-hydroxy-N-methyl-quinolinium esters (2-5), and two other ...