Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

…, CG Yannopoulos, N Nguyen-Ba, D Labrecque…

Index: Chan, Laval; Das, Sanjoy K.; Reddy, T. Jagadeeswar; Poisson, Carl; Proulx, Melanie; Pereira, Oswy; Courchesne, Marc; Roy, Caroline; Wang, Wuyi; Siddiqui, Arshad; Yannopoulos, Constantin G.; Nguyen-Ba, Nghe; Labrecque, Denis; Bethell, Richard; Hamel, Martine; Courtemanche-Asselin, Philippe; L'Heureux, Lucille; David, Maud; Nicolas, Olivier; Brunette, Stephanie; Bilimoria, Darius; Bedard, Jean Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 793 - 796

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Citation Number: 81

Abstract

In 1989, Hepatitis C virus (HCV) was identified as the pathogen responsible for the majority of the cases of non-A non-B hepatitis. This positive strand RNA virus of the Flaviviridae family chronically infects approximately 3% of the world population or 175 million individuals causing severe liver malfunction and morbidity. To date, there is no prophylactic vaccine and the recommended treatments, interferon α2b or a pegylated conjugate (PEG-Intron®) alone or in ...