Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors

S Ozcan, A Kazi, F Marsilio, B Fang…

Index: Journal of Medicinal Chemistry, , vol. 56, # 10 p. 3783 - 3805

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Citation Number: 10

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The screening hit 1 was identified as a CT-L proteasome inhibitor with an IC 50 value of 0.60 ± 0.18 μM (in vitro). Validation of the synthetic route to 1 was undertaken to confirm ...