Synthesis of some functionalized arylaminomethyl-1, 2, 4-triazoles, 1, 3, 4-oxa-and thiadiazoles

MT Abdel-Aal, WA El-Sayed…

Index: Abdel-Aal, Mohammed T.; El-Sayed; Aleem, A. H. Abdel; El Ashry Pharmazie, 2003 , vol. 58, # 11 p. 788 - 792

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Citation Number: 13

Abstract

Thiosemicarbazides undergo different cyclization reactions to give five membered heterocycles. The product of cyclization depends on the reagent used. This cyclization leads to the formation of 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4-triazole derivatives. The reaction of thioglycolyl hydrazide derivatives of the 1, 2, 4-triazole compounds was discussed. The activity against hepatitis B virus (HBV) has been tested.