Synthesis and antimicrobial activity of 4-substituted 2-cycloalkylquinolines

…, MN Zemtsova, PL Trakhtenberg, DA Kulikova…

Index: Moiseev, I. K.; Zemtsova, M. N.; Trakhtenberg, P. L.; Kulikova, D. A.; Skobkina, I. P.; et al. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 12 p. 893 - 896 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 12 p. 1448 - 1451

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Abstract

Continuing work on the synthesis and examination of the biological activity of 2-R'-4-R- quinolines, it was considered desirable to develop convenient methods for the synthesis of 2- cycloalkylquinoline-4-carboxylic acids and their derivatives. In this connection, it was of importance to establish the influence of a cycloalkyl substituent in the 2-position of the quinoline ring on biological activity. This made it possible to compare the properties and ...