Arkivoc

Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalysed cross-coupling reactions

…, V Martynaitis, S Krikštolaitytė, W Holzer…

Index: Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackus, Algirdas Arkivoc, 2011 , vol. 2011, # 11 p. 1 - 21

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Citation Number: 7

Abstract

Abstract An efficient synthetic route to construct ortho-substituted 1-phenyl-1H-pyrazole-4- carboxaldehydes and the corresponding ethanones starting from 1-phenyl-1H-pyrazol-3-ol is described. Carbon-carbon bond-forming Pd-catalysed cross-coupling reactions were applied for the functionalisation of the intermediate pyrazole triflates. Detailed NMR spectroscopic investigations were undertaken with all obtained products. Keywords: ...