A series of (+)-cis-N-normetazocine derivatives has been described, and their affinities for σ1, σ2, and phencyclidine (PCP) sites and opioid, muscarinic (M2), dopamine (D2), and serotonin (5-HT2) receptors were evaluated. The effect of the N-substitution with a substituted ethylamino spacer was investigated. Compounds 8c-11c displayed high affinities for σ1 sites and for opioid receptors. Substitution of the second basic nitrogen either with ...
