Synthesis

Enantioselective Synthesis of the PPARα Agonist (R)-K-13675 via (S)-2-Hydroxybutyrolactone

Y Yamazaki, T Araki, M Koura, K Shibuya

Index: Synthesis, , # 7 p. 1017 - 1022

Full Text: HTML

Citation Number: 5

Abstract

... Scheme 2 Synthesis of (R)-K-13675 ... 7, H, DEAD, MeCN, trace, ... a Conditions: entries 1-4: 2 (100 mg), 12a or 12b (1.2 equiv), base (1.2 equiv), rt, 2 d; entries 5-15: 2 (100 mg), 4 (2.0 equiv), Ph 3 P (2.0 equiv), azodicarboxylates or TMAD (2.0 equiv), rt, 1 d; entry 16: 2 (100 mg), 4 (2.0 ...