Bulletin of the Chemical Society of Japan

A New Method for the Preparation of Piperazines. I. Preparation of N-Mono-alkyl (-aryl)-piperazines

K Nakajima

Index: Nakajima,K. Bulletin of the Chemical Society of Japan, 1961 , vol. 34, p. 651 - 654

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Citation Number: 5

Abstract

С2Н5//216 224 232 251 274 295 (dec.) 9.51 9.58** reduced pressure. Some physical properties of II are summarized in Table I. The second stage is the acetylation of the secondary amino and hydroxyl group in II, which can be effected by two equivalent amounts of acetic anhydride. The reaction proceeds spontaneously with the evolution of heat, and the subsequent distillation under reduced pressure gives III almost in a quantitative yield.