Summary Six derivatives of p-(0-aminopheny1)-benzene sulfonamide, in which a hydrogen of the sulfonamide nitrogen was replaced by an aryl group were prepared from p-(0- aeetamidopheny1)-ben-zenesulfonyl chloride and from p-(0-nitropheny1)-benzenesulfonyl chloride. These and the parent compound were inactive when tested in vitro against E. Coli and in vivo against streptococcal infected mice.