The title compound (l), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver (I1) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate synthetase (methotrexate-resistant Lactobacillus casei) and saturation kinetics, and the inactivation is responsive to substrate protection. The inactivation is not reversible on prolonged dialysis ...
![5-(2,5-dimethoxyphenyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Structure](https://image.chemsrc.com/caspic/312/76756-32-6.png)
