Open-chain nitrogen compounds. Part VI. The formation of bis (1-aryl-3-methyltriazen-3-ylmethyl) methylamines in the reaction of diazonium ions with mixtures of …

…, CM Hemens, RJ LaFrance, Y Tang…

Index: Manning, Hartford W.; Hemens, Chantal M.; LaFrance, Ronald J.; Tang, York; Vaughan, Keith Canadian Journal of Chemistry, 1984 , vol. 62, p. 749 - 754

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Citation Number: 14

Abstract

The synthesis of a series of N, N-bis (1-aryl-3-methyltriazen-3-ylmethyl) methylamines from coupling diazonium salts with mixtures of methylamine and formaldehyde is described. These novel bis-triazenes, or heptazanonadienes, have significant anti-tumour activity against the TLX5 lymphoma in mouse. The mechanism of formation of these triazenes is discussed with reference to the implication to the presumed equilibria taking place in the ...