Abstract A general and versatile method for the preparation of 2H-thiopyrano [2, 3-b] pyridin- 2-ones is described. The starting materials, the β, β-disubstituted vinyl-1-t-butyl-2-(1H) pyridinethiones were prepared from the synthon 3-formyl-1-t-butyl-2-(1H) pyridinethione by