Tetrahedron: Asymmetry

Enantioselective acylation of chiral amines catalysed by aminoacylase I

MI Youshko, F van Rantwijk, RA Sheldon

Index: Youshko, Maxim I; Van Rantwijk, Fred; Sheldon, Roger A Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3267 - 3271

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Citation Number: 31

Abstract

Aminoacylase (EC 3.5. 1.14) from Aspergillus melleus mediated the acylation of the primary amino group in a range of primary arylalkylamines and amino alcohols in anhydrous organic medium. The commonly used vinyl and isopropenyl esters proved to be unsuitable acyl donors because rapid uncatalysed aminolysis occurred in the presence of these additives. The unwanted aminolysis reaction could be suppressed by performing the enzymatic ...