During the course of our investigations into the 1,3-dipolar cycloaddition of nitroindoles 7 and nitrovinylindoles 8 with münchnones, we became interested in developing a similar approach to a variety of pyridylpyrroles which would allow aryl substitution at any position of the pyridine core. Nitroalkenes 5 and 6 were accessed via a modified Henry reaction reported by Hills 9 which uses a catalytic amount of 1,1,3,3-tetramethylguanidine (TMG) to generate the β-nitro ...
![2-[(E)-2-nitroethenyl]quinoline Structure](https://image.chemsrc.com/caspic/219/68311-65-9.png)