Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

RB Perni, SC Conway, SK Ladner, K Zaifert…

Index: Perni, Robert B.; Conway, Samuel C.; Ladner, Stephanie K.; Zaifert, Katie; Otto, Michael J.; King, Robert W. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 23 p. 2687 - 2690

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Citation Number: 44

Abstract

A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure–activity relationships of this series are discussed.