Synthesis

An efficient method for the preparation of versatile building blocks: 1-substituted 2, 2-dimethoxyethylamine hydrochlorides

B Liu, D Su, G Cheng, H Liu, X Wang, Y Hu

Index: Liu, Bo; Su, Deyong; Cheng, Guolin; Liu, Hui; Wang, Xinyan; Hu, Yuefei Synthesis, 2009 , # 19 p. 3227 - 3232

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Abstract

Abstract A novel method for the preparation of 1-substituted 2, 2-dimethoxyethylamine hydrochlorides was developed. The method includes three highly efficient steps:(1) direct use of aqueous (MeO) 2 CHCHO for the preparation of N, O-acetal by condensation with Betti base without acidic catalyst;(2) regioselective alkylations of the N, O-acetal with Grignard reagents; and (3) Pd/C catalytic hydrogenolyses of benzylamines in the ...

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