Journal of the American Chemical Society

On cysteine and cystine peptides. I. New S-protecting groups for cysteine

L Zervas, I Photaki

Index: Zervas,L.; Photaki,I. Journal of the American Chemical Society, 1962 , vol. 84, p. 3887 - 3897

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Citation Number: 141

Abstract

Introduction An attempt by Fischer and Gerngross3 to prepare monoglycyl-and monoleucyl- L-cystine through aminolysis of their respective monohaloacyl-L-cystine precursors resulted in the formation, in each instance, of a dipeptide which was not pure and appreciable amounts of cystine. This unusual aminolysis of an a-haloacylamino acid can be easily explained4 by the well-known fact that un-symmetrical open chain derivatives of cystine ( ...