Two thiazole analogs of folic acid, in which the benzene ring is replaced by a thiazole ring, were synthesized as part of a continuing program to design and obtain folic acid analogs with a potentially altered ability to function as one-carbon transfer agents. The reductive condensation of 2-acetamido-6-formylpteridin-4 (3H)-one (3) with diethyl N-[(2-amino-4- thiazolyl) carbonyl] glutamate (2) followed by hydrolysis of the blocking groups afforded ...
![L-Glutamic acid,N-[(2-amino-4-thiazolyl)carbonyl]-, diethyl ester (9CI) Structure](https://image.chemsrc.com/caspic/222/40283-42-9.png)
![diethyl 2-[(2-amino1,3-thiazole-5-carbonyl)amino]pentanedioate Structure](https://image.chemsrc.com/caspic/022/40283-47-4.png)
![2-[[2-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]1,3-thiazole-5-carbonyl]amino]pentanedioic acid Structure](https://image.chemsrc.com/caspic/354/37746-94-4.png)