Alkylations of Phenylacetic Esters with Halides by Means of Sodium Amide in Liquid Ammonia. Comparisons with Alkylations of Phenylacetic Acid1a

WG Kenyon, RB Meyer, CR Hauser

Index: Kenyon,W.G. et al. Journal of Organic Chemistry, 1963 , vol. 28, p. 3108 - 3112

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Citation Number: 15

Abstract

Ethyl phenylacetate was alkylated with alkyl and aralkyl halides through the sodio ester, which was prepared by means of sodium amide in liquid ammonia. The methyl, n-butyl, benzyl, and the a-and p-phenylethyl derivatives uere obtained in high yields but the a $- diphenylethyl derivative wes produced in only fair yield along with stilbene. Similarly, t-butyl phenylacetate was alkylated with representative halidee through the sodio ester. The a- ...