2, 3-Dialkyl (dimethylamino) indoles, synthesized via the Fisher indole synthesis, were found to weakly bind to 5HT1 and 5HTz sites in brain cortical membranes (IC6o greater than 1 pM at both sites for all compounds). These (dimethy1amino) indoles were relatively potent antagonists of the serotonin receptor in the rat stomach fundus. At higher concentrations, several of the compounds were weak agonists at this receptor. For direct comparison with ...
