Synthesis and evaluation of novel polyaminocarboxylate-based antitumor agents

HS Chong, X Ma, H Lee, P Bui, HA Song…

Index: Chong, Hyun-Soon; Ma, Xiang; Lee, Haisung; Bui, Phuong; Song, Hyun A.; Birch, Noah Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2208 - 2215

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Citation Number: 15

Abstract

Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer. We synthesized and evaluated novel polyaminocarboxylate-based chelators NETA, NE3TA, and NE3TA-Bn and their bifunctional versions C-NETA, C-NE3TA, and N-NE3TA for use in iron depletion tumor therapy. The cytotoxic activities of the novel polyaminocarboxylates were evaluated in the ...