Acyl Hydrazides: Potent Antioxidants

…, S Moazzam Haider, M Iqbal Choudhary…

Index: Khan, Khalid Mohammed; Rani, Mubeen; Ambreen, Nida; Ejaz, Asma; Perveen, Shahnaz; Haider, Syed Moazzam; Choudhary, Mohammad Iqbal; Voelter, Wolfgang Letters in Drug Design and Discovery, 2012 , vol. 9, # 2 p. 135 - 139

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Abstract

Twenty-eight acyl hydrazides (1-28) are subjected for nitric oxide scavenging activities and their structureactivity relationship (SAR) is established. Compounds 1-28 showed a varying degree of activity having IC50 values in the range of 9.1±6.5-231.1 μM. It was found that twenty-five (25) out of twenty-eight (28) compounds, showed an excellent nitric oxide scavenging activity. It was observed that the activity mainly depends on the substitution on ...