Expedient synthesis of highly substituted pyrroles via tandem rearrangement of α-diazo oxime ethers

Y Jiang, WC Chan, CM Park

Index: Jiang, Yaojia; Chan, Wei Chuen; Park, Cheol-Min Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4104 - 4107

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Citation Number: 78

Abstract

An efficient rhodium-catalyzed synthesis of 2 H-azirines and pyrroles has been developed. Novel rearrangement of α-oximino ketenes derived from α-diazo oxime ethers provides 2 H- azirines bearing quaternary centers and allows for subsequent rearrangement to highly substituted pyrroles in excellent yields.