Effective oxidation of secondary amines to nitrones with alkyl hydroperoxides catalysed by (trialkanolaminato) titanium (IV) complexes

M Forcato, M Mba, WA Nugent…

Index: Forcato, Massimiliano; Mba, Miriam; Nugent, William A.; Licini, Giulia European Journal of Organic Chemistry, 2010 , # 4 p. 740 - 748

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Citation Number: 7

Abstract

Abstract The effective catalytic oxidation of secondary amines to nitrones with alkyl hydroperoxides as the primary oxidants is described. The titanium alkoxide catalysts are protected from the water co-product by the combined use of a tightly binding trialkanolamine ligand and molecular sieves. Nitrones can be obtained in high yields (up to 98%) under homogeneous, anhydrous conditions and even in the absence of solvent. The reactions ...