Efficient Hydrolysis of Nitriles to Amides with Hydroperoxide Anion in Aqueous Surfactant Solutions as Reaction Medium

…, L Goracci, P Di Profio, R Germani

Index: Brinchi, Lucia; Chiavini, Lisa; Goracci, Laura; Di Profio, Pietro; Germani, Raimondo Letters in Organic Chemistry, 2009 , vol. 6, # 2 p. 175 - 179

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Citation Number: 5

Abstract

Aliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H2O2 in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of environmentally benign oxidant H2O2, easy product isolation, short reaction time, high yields and selectivity, mild conditions.