Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

…, SH Seo, YY Baek, H Rhim, YS Cho, H Choo…

Index: Lee, Jie Eun; Koh, Hun Yeong; Seo, Seon Hee; Baek, Yi Yeon; Rhim, Hyewhon; Cho, Yong Seo; Choo, Hyunah; Pae, Ae Nim Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4219 - 4222

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Citation Number: 14

Abstract

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives substituted with arylpiperazinylalkylamines. The oxazoles were synthesized in a convenient convergent synthetic method, and biologically evaluated against α1G (CaV3. 1) T-type calcium ...