Serotonin derivatives, major safflower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein …

…, K Suzuki, H Arisaka, T Nakano, Y Amino…

Index: Koyama, Naoto; Kuribayashi, Kanna; Seki, Tetsuya; Kobayashi, Katsunori; Furuhata, Yasufumi; Suzuki, Katsuya; Arisaka, Harumi; Nakano, Takashi; Amino, Yusuke; Ishii, Koichi Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 14 p. 4970 - 4976

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Citation Number: 87

Abstract

The effects of defatted safflower seed extract and its phenolic constituents, serotonin derivatives, on atherosclerosis were studied. Ethanol-ethyl acetate extract of safflower seeds (SSE) inhibited low-density lipoprotein (LDL) oxidation induced in vitro by an azo-containing free-radical initiator V70 or copper ions. Two serotonin derivatives [N-(p-coumaroyl) serotonin, CS; N-feruloylserotonin, FS] and their glucosides were identified as the major ...