Synthesis and biological activity of modified fragments of the antibiotic bleomycin A 2

SE Bannikov, GP Andronnikova, NS Vyrupaeva…

Index: Bannikov, S. E.; Andronnikova, G. P.; Vyrupaeva, N. S.; Glibin, E. N.; Pushkareva, Z. V. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 2 p. 109 - 112 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 2 p. 164 - 167

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Abstract

The synthesis of 2'-(2-aminoethyl)-2, 4'-bithiazole-4-N-(3-dimethylaminopropyl) carboxamid,(III) was carried out from the trifluoroacetylated amino acid II (V) by the acid chloride method, as in the analogous synthesis of fragment (I)[I]. For this purpose, the previously described [4] ethyl 2'-(2-phthalimidoethyl)-2, 4'-bithiazole-4-carboxylate (VI) was subjected to acid hydrolysis in concentrated hydrochloric acid to give the hydrochloride of ...